Journal article
General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance
A Fornito, J Yoon, A Zalesky, ET Bullmore, CS Carter
Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2011
Abstract
Background: Cognitive control impairments in schizophrenia are thought to arise from dysfunction of interconnected networks of brain regions, but interrogating the functional dynamics of large-scale brain networks during cognitive task performance has proved difficult. We used functional magnetic resonance imaging to generate event-related whole-brain functional connectivity networks in participants with first-episode schizophrenia and healthy control subjects performing a cognitive control task. Methods: Functional connectivity during cognitive control performance was assessed between each pair of 78 brain regions in 23 patients and 25 control subjects. Network properties examined were regi..
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Awarded by National Institutes of Health
Funding Acknowledgements
AF was supported by a National Health and Medical Research Council CJ Martin Fellowship (Grant No. 454797). JHY was supported by the National Institutes of Health. AZ was supported by the Australian Research Council (Grant No. DP0986320).